Research progress in role of programmed cell death-1 on HIV infection, prevention and treatment
10.3760/cma.j.cn112309-20201009-00463
- VernacularTitle:程序性死亡受体1在HIV感染和防治中的作用研究进展
- Author:
Xiaoxiao LIU
1
;
Min ZHUANG
;
Hong LING
;
Jiaye WANG
Author Information
1. 哈尔滨医科大学微生物学教研室，黑龙江省感染与免疫重点实验室，黑龙江省普通高校病原生物学重点实验室 150081
- Keywords:
Programmed death-1;
Human immunodeficiency virus;
Infection;
Prevention and treatment
- From:
Chinese Journal of Microbiology and Immunology
2021;41(6):473-478
- CountryChina
- Language:Chinese
-
Abstract:
Programmed death-1 (PD-1) is an immunosuppressive molecule on the surface of several cells, and functions as a negative regulatory factor in cellular and humoral immune responses via interaction with its ligand PD-L1 or PD-L2. The expression of PD-1 on the peripheral blood lymphocytes of human immunodeficiency virus (HIV) infected people is commonly up-regulated, which not only affects the susceptibility of the virus to target cells and the host′s antiviral immune response, but also affects the effect of antiretroviral therapy. In vitro blocking PD-1/PD-L pathway showed improved HIV-specific immune response of host cells, and PD-1 blockade and/or PD-L1 blockade have been used as an auxiliary means to enhance the efficacy of antiviral therapy and HIV vaccines. This article reviews the progress of the studies on PD-1 in HIV infection, prevention and treatment.
