The effect of combining transcranial magnetic stimulation with escitalopram on neurological functioning, depression and serum inflammatory factors after a stroke
10.3760/cma.j.issn.0254-1424.2021.09.005
- VernacularTitle:高频重复经颅磁刺激联合艾司西酞普兰对脑卒中后抑郁患者神经功能、抑郁状态及其血清炎症因子的影响
- Author:
Yanfang SUI
1
;
Zhenhua SONG
;
Ji ZENG
;
Jin WU
;
Yong CHEN
;
Tiecheng GUO
Author Information
1. 中南大学湘雅医学院附属海口医院康复医学科,海口 570208
- Keywords:
Transcranial magnetic stimulation;
Escitalopram;
Stroke;
Depression;
Inflammation
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2021;43(9):793-796
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of combining repeated high-frequency transcranial magnetic stimulation (rTMS) with escitalopram in treating the neurological functioning and post-stroke depression of stroke survivors.Methods:Eighty persons with post-stroke depression were randomly divided into an observation group and a control group, each of 40. The control group was treated with oral escitalopram, while the observation group also received transcranial magnetic stimulation at 5Hz. The magnetic stimulation intensity was 80% of each person′s resting motion threshold. The rTMS was administered once a day, 5 days a week for 8 weeks. Neurological functioning and depression were evaluated using National Institutes of Health stroke scoring (NIHSS) and the Hamilton depression scale before and after the 8 weeks of treatment. The levels of tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2) and interleukin-6 (IL-6) in serum samples from the two groups were detected using enzyme-linked immunosorbent assays.Results:After treatment, the NIHSS and Hamilton scores and TNF-α, IL-2 and IL-6 levels in both groups had improved significantly, but in each case they were significantly better in the treated group, on average.Conclusion:Supplementing escitalopram with high-frequency transcranial magnetic stimulation more effectively improves depression and neurological functioning after a stroke.