Progress on pravastatin and its safety in prevention and treatment of preeclampsia
10.3760/cma.j.cn113903-20210325-00262
- VernacularTitle:普伐他汀防治子痫前期的有效性及安全性的研究进展
- Author:
Hongyu LIU
1
;
Mengjie TANG
;
Leilei ZHANG
;
Jinxiang GAO
;
Shihui YANG
Author Information
1. 滨州医学院附属医院妇产科 256600
- Keywords:
Preeclampsia;
Pravastatin;
Treatment outcome;
Validation studies
- From:
Chinese Journal of Perinatal Medicine
2021;24(11):862-867
- CountryChina
- Language:Chinese
-
Abstract:
Preeclampsia is the main cause of poor maternal-fetal outcomes. A series of cell and animal experiments, and a small number of clinical studies have shown that pravastatin can prevent and treat preeclampsia by regulating angiogenesis, increasing the expression of heme oxygenase, and stimulating the production of nitric oxide without any reported adverse effects during pregnancy. We review the latest progress on the mechanism, effect, and safety of pravastatin in the prevention and treatment of preeclampsia.
