Schaaf-Yang syndrome in a neonate caused by MAGEL2 gene mutation: a case report
10.3760/cma.j.cn113903-20210312-00209
- VernacularTitle:MAGEL2基因变异致新生儿Schaaf-Yang 综合征一例
- Author:
Zhongwen HUANG
1
;
Lin YANG
;
Bingbing WU
;
Huijun WANG
Author Information
1. 复旦大学附属儿科医院分子医学中心，上海 201102
- Keywords:
Respiratory insufficiency;
Muscle hypotonia;
Intellectual disability;
Neurodevelopmental disorders;
Proteins;
Mutation;
Whole exome sequencing;
Infant, newbo
- From:
Chinese Journal of Perinatal Medicine
2021;24(11):858-861
- CountryChina
- Language:Chinese
-
Abstract:
In this study, we reported a patient with neonatal-onset Schaaf-Yang syndrome (SYS). The girl was the second singleton child of a healthy, nonconsanguineous couple. She suffered from hypoxic asphyxia at birth and soon developed persistent respiratory distress. She was also diagnosed with neonatal encephalopathy, congenital heart disease, pneumonia, sepsis, neonatal jaundice, congenital laryngeal achondroplasia, and paralysis of vocal cord were diagnosed after admission. She spent the first one month of life in the neonatal intensive care unit and was treated with mechanical ventilation, nutritional support and anti-infectives. Then the baby was discharged as her parents' request and died of respiratory failure at the age of 2 months. Whole exome sequencing detected, a heterozygous nonsense mutation of c.1912C>T(p.Q638X) in MAGEL2 in the fetus, which was inherited from her father but not found in her mother.
