Research progress on fetal RHD genotype screening in RhD-negative pregnant women in Asia
10.3760/cma.j.cn113903-20210312-00211
- VernacularTitle:亚洲RhD阴性血型孕妇胎儿 RHD基因型检测研究进展
- Author:
Zihan JIANG
1
;
Jie LI
;
Honglei DUAN
Author Information
1. 南京医科大学鼓楼临床医学院妇产科 210008
- Keywords:
Rh-Hr blood-group system;
Pregnant women;
Genotype;
Rho(D) immune globulin;
Fetus;
Genetic testing;
Prenatal diagnosis
- From:
Chinese Journal of Perinatal Medicine
2021;24(10):793-797
- CountryChina
- Language:Chinese
-
Abstract:
RhD-negative pregnant women with an RhD-positive fetus are at risk of hemolytic disease of the fetus and newborn (HDFN), which may lead to fetal/neonatal death. While these would not affect those RhD-negative fetuses. With the advancement of technology in genetics, the administration of anti-D immunoglobulin to women with an RhD-positive fetus could reduce the risk of HDFN. Therefore, non-invasive prenatal testing on fetal RHD genotype plays an important role in the management of RhD-negative pregnant women. Selective usage of anti-D immunoglobulin is important in perinatal management in these women. The non-invasive prenatal screening for fetal RHD gene which has been carried out in Caucasian is not applicable to Asians because of the difference in RHD genotype. In addition to complete or partial RHD gene deletion, point mutations are also common RHD genotypes among Asians. This enlightens us to establish a non-invasive prenatal screening method for Asians. This article reviews the progress of fetal RHD screening in Asian RhD-negative pregnant women.
