A case report of staphylococcal protein A immunoadsorption therapy for refractory myasthenia gravis
10.3760/cma.j.cn113694-20210314-00186
- VernacularTitle:葡萄球菌蛋白A免疫吸附治疗难治性重症肌无力一例
- Author:
Qile XIAO
1
;
Xiaomei WU
;
Jiajun LIU
;
Hainan ZHANG
Author Information
1. 中南大学湘雅二医院神经内科，长沙410011
- Keywords:
Myasthenia gravis;
Immunoadsorption therapy;
Staphylococcal protein A
- From:
Chinese Journal of Neurology
2021;54(12):1295-1298
- CountryChina
- Language:Chinese
-
Abstract:
Staphylococcal protein A (SPA) has a high affinity for human immunoglobulin, and SPA immunoadsorption can specifically reduce the titer of autoantibodies and quickly relieve the clinical symptoms of myasthenia gravis (MG). Recent studies have suggested that immunoadsorption has better clinical efficacy and a lower incidence of adverse reactions than plasma exchange. A case of refractory MG with poor response to corticosteroids, intravenous immunoglobulins and immunosuppressive therapy was reported. The patient had low immune function and progressive pulmonary infection in the later stage of the disease. Respiratory muscle weakness was relieved quickly after four times of immunoadsorption therapy. The value of immunoadsorption in the treatment of refractory MG was explored with literature review.
