A case report of spinocerebellar ataxia type 2 with parkinsonism and cognitive impairment
10.3760/cma.j.cn113694-20210517-00344
- VernacularTitle:伴帕金森样症状和认知下降的脊髓小脑共济失调2型一例
- Author:
Wei DU
1
;
Shuhua LI
Author Information
1. 北京医院神经内科 100730
- Keywords:
Spinocerebellar ataxia;
Parkinsonian disorders;
Cognition disorders
- From:
Chinese Journal of Neurology
2021;54(12):1290-1294
- CountryChina
- Language:Chinese
-
Abstract:
The common clinical manifestations of spinocerebellar ataxia type 2 include ataxia, dysarthria, slower saccades, weakened or disappeared tendon reflexes, etc. It is relatively rare in patients with parkinsonism and cognitive impairment. Parkinsonism is rare in patients with spinocerebellar ataxia type 2, maybe because the degeneration of the substantia nigra striatum system is only manifested in the striatal presynaptic membrane, while the postsynaptic membrane receptors are relatively retained. At the same time, the degeneration of the subthalamic nucleus and the cerebellum prevents parkinsonism.The reason for cognitive decline may be related to the decrease in the network connection between the cerebellum and cerebral cortex in spinocerebellar ataxia type 2 patients.
