Postinfectious inflammatory response syndrome in patients with cryptococcal meningitis
10.3760/cma.j.cn113694-20210222-00133
- VernacularTitle:隐球菌脑膜炎患者感染后炎性反应综合征
- Author:
Bang′e QIN
1
;
Jia LIU
;
Fuhua PENG
;
Ying JIANG
Author Information
1. 中山大学附属第三医院神经病学科，广州 510630
- Keywords:
Meningitis, cryptococcal;
Immune reconstitution inflammatory syndrome;
Post-infectious inflammatory response syndrome;
Parainfectious inflammatory syndro
- From:
Chinese Journal of Neurology
2021;54(11):1198-1202
- CountryChina
- Language:Chinese
-
Abstract:
Cryptococcal meningitis is a common fungal meningitis that may present with an abnormal immune response during effective antifungal therapy and is called immune reconstitution inflammatory syndrome in human immunodeficiency virus (HIV)-infected patients. Similar phenomenon can also be seen in non-HIV patients with normal immune function in the past. Paradoxical clinical and/or imaging deterioration occurs due to strong immune response during treatment, which is called post-infectious inflammatory response syndrome. At present, it has not attracted attention. This complication is an important cause of poor prognosis in non-HIV patients. Early identification and treatment of post-infectious inflammatory response syndrome is of great significance. This article will review its possible pathogenesis, clinical manifestations, imaging characteristics, risk prediction, diagnosis, treatment and prognosis.
