Research progress of single nucleotide polymorphisms of risk gene of restless legs syndrome
10.3760/cma.j.cn113694-20210308-00170
- VernacularTitle:不宁腿综合征风险基因单核苷酸多态性的研究进展
- Author:
Baoyan WANG
1
;
Wei WU
Author Information
1. 天津医科大学总医院空港医院神经内科300308
- Keywords:
Restless legs syndrome;
Genes;
Polymorphism, single nucleotide
- From:
Chinese Journal of Neurology
2021;54(11):1187-1193
- CountryChina
- Language:Chinese
-
Abstract:
Restless legs syndrome (RLS) is a kind of common diseases of the nervous system, of which adult prevalence rate is from 1% to 15%. The etiology, pathogenesis and related gene therapy of RLS are not fully understood. Studies have shown that RLS may be associated with the polymorphism of some risk genes. Genome-wide association studies have revealed a total of seven risk sites to date, including MEIS1, BTBD9, MAP2K5/SKOR1, PTPRD, TOX3, NOS1 and 2p14 intergenic regions. This article reviewed the research progress of single nucleotide polymorphisms in RLS risk genes in recent years.
