Apraxia of Creutzfeldt-Jakob disease: a case report
10.3760/cma.j.cn113694-20210301-00151
- VernacularTitle:以失用症为突出表现的克雅病一例
- Author:
Jie WANG
1
;
Jingwen NIU
;
Longze SHA
;
Heyang SUN
;
Shanshan CHU
;
Jing GAO
Author Information
1. 中国医学科学院北京协和医院疑难重症及罕见病国家重点实验室100730
- Keywords:
Creutzfeldt-Jakob syndrome;
Apraxia, ideomotor;
Case reports
- From:
Chinese Journal of Neurology
2021;54(11):1181-1186
- CountryChina
- Language:Chinese
-
Abstract:
The clinical manifestations and examination results of a case of Creutzfeldt-Jakob disease (CJD) admitted to the Department of Neurology of Peking Union Medical College Hospital,Chinese Academy of Medical Sciences in August 2020 were analyzed, and a comprehensive neuropsychological assessment and assessment of apraxia were conducted. The neuropsychological characteristics of apraxia in CJD patient and the progress in the research and evaluation of apraxia were reviewed. The patient was a 65-year-old male with insidious onset and progressive symptoms, whose clinical manifestations were apraxia, rapidly progressing dementia, and extrapyramidal symptoms. The magnetic resonance imaging showed hyper-intense signal in diffusion weighted imaging in bilateral cerebral hemispheres, and 14-3-3 protein in cerebrospinal fluid was positive, which were consistent with the probable CJD diagnostic criteria. The patient exhibited prominent signs and symptoms of ideomotor apraxia. It has been reported in the literature that apraxia can also be the main neuropsychological manifestation of CJD. It is necessary to pay attention to the standard evaluation and timely identification of apraxia in clinical diagnosis.
