Progress in diagnosis and treatment of antibody-related autoimmune cerebellar ataxia

VernacularTitle:抗体相关自身免疫性小脑性共济失调的诊疗进展
Author: Mange LIU ¹ ; Hongzhi GUAN ; Haitao REN ; Liying CUI
Author Information

1. 中国医学科学院北京协和医院神经科　100730
Keywords: Cerebellum; Ataxia; Autoimmunity; Antibodies
From: Chinese Journal of Neurology 2021;54(8):857-861
CountryChina
Language:Chinese
Abstract: Cerebellar ataxia mediated by autoimmune mechanisms is a common cause of sporadic cerebellar ataxia. According to the presence of underlining malignancy, autoimmune cerebellar ataxia (ACA) can be divided into paraneoplastic ACA and non-paraneoplastic ACA. The typical manifestations of various types of ACA include gait disorder, limb and trunk ataxia, mild inflammatory response and specific oligoclonal bands in cerebrospinal fluid. Immunosuppressive therapy might be effective. Anti-neuronal antibodies are of great significance to the diagnosis of ACA, and the discovery of the new antibody profile has promoted a deeper understanding of ACA. This article reviews the clinical features and progress of diagnosis and treatment of ACA.