Research progress of neurofilament light chain in the parkinsonism

VernacularTitle:神经丝蛋白轻链与帕金森综合征相关研究进展
Author: Yi XIAO ¹ ; Lingyu ZHANG ; Ruwei OU ; Chunyu LI ; Huifang SHANG
Author Information

1. 四川大学华西医院神经内科，成都610041
Keywords: Parkinson disease; Diagnosis; Prognosis; Neurofilament light chain; Parkinsonism plus syndrome
From: Chinese Journal of Neurology 2021;54(8):843-847
CountryChina
Language:Chinese
Abstract: Neurofilament light chain (NfL), a sensitive biomarker of axonal damage, was found increasing in several neurological diseases. Parkinsonism is a group of clinical syndromes characterized by cardinal symptoms of bradykinesia, rigidity, and tremor, including Parkinson′s disease (PD) and parkinsonism plus syndrome (PPS). It is difficult in the diagnosis and differential diagnosis of PD and PPS, especially in the early stage. Evidence suggests that NfL in the cerebrospinal fluid and blood is a promising biomarker for the differential diagnosis of PD and PPS. This article reviewed and summarized the research progress of value of NfL in PD and PPS, and proposed future research directions.