Recent advance of aquaporin-4 in neurodegenerative diseases
10.3760/cma.j.cn113694-20201103-00842
- VernacularTitle:水通道蛋白4在神经退行性疾病中的研究进展
- Author:
Zhiyun WANG
1
;
Xiaoli SI
;
Jiali PU
;
Baorong ZHANG
Author Information
1. 浙江大学医学院附属第二医院神经内科，杭州310009
- Keywords:
Neurodegenerative disease;
Aquaporin-4;
Glymphatic system
- From:
Chinese Journal of Neurology
2021;54(8):838-843
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative disease is a type of disease characterized by the progressive loss of neurons, the cause of which is not clear. Aquaporin-4 (AQP4) is a member of the aquaporin family, which plays an important role in maintaining water homeostasis in the brain. In recent years, researchers found that AQP4 has the functions of draining brain metabolic wastes and participating in material exchange through the glmphatic system. This review aims to summarize the current researches of AQP4 in the pathogenesis and progression of neurodegenerative diseases such as Parkinson′s disease and Alzheimer′s disease, and to propose future research directions.
