The glymphatic system: a new exploration of the clearance of alpha-synuclein in Parkinson′s disease
10.3760/cma.j.cn113694-20210128-00073
- VernacularTitle:脑胶质-淋巴系统——帕金森病α-突触核蛋白清除机制的新探索
- Author:
Jiali PU
1
;
Baorong ZHANG
Author Information
1. 浙江大学医学院附属第二医院神经内科，杭州 310009
- Keywords:
Parkinson disease;
α-Synuclein;
Glymphatic system
- From:
Chinese Journal of Neurology
2021;54(8):758-761
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson′s disease (PD) is a common neurodegenerative disease. Impaired balance between deposition and clearance of α-synuclein lies at the core of PD pathogenesis. The glymphatic system is a highly organized fluid transport system that is capable of removing brain waste. Emerging evidence revealed that glymphatic dysfunction plays a critical role in the pathogenesis of neurodegenerative diseases, yet study on its implication in PD is at its early stage. An in-depth study of the relationship between the function of the glymphatic system and α-synuclein clearance in PD may shed light on the pathogenesis and therapeutics of the disease.
