Research progress on the association between Parkinson′s disease and inflammatory bowel disease in genetics and gut microbiota
10.3760/cma.j.cn113694-20201028-00817
- VernacularTitle:帕金森病与炎性肠病在遗传学和肠道微生物方面的关联研究进展
- Author:
Yanghong LI
1
;
Xiaoxia ZHOU
;
Beisha TANG
Author Information
1. 中南大学湘雅医院神经内科，长沙 410008
- Keywords:
Parkinson disease;
Inflammatory bowel disease;
LRRK2 gene;
Gut microbiota;
Gut-brain axis
- From:
Chinese Journal of Neurology
2021;54(7):734-742
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson′s disease (PD) is a common degenerative disease of central nervous system. PD is closely related to gastrointestinal diseases in comorbidity studies, and the “gut brain axis” disorder may be involved in their relationship. In recent years, relevant studies have suggested that there are genetic and epidemiological evidences to link PD with inflammatory bowel disease (IBD). This article reviews the relationship between PD and IBD from the genetic evidence and the relevant concept of “gut brain axis”.
