Research progress on the effect of single nucleotide polymorphism on drug efficacy of Alzheimer′s disease
10.3760/cma.j.cn113694-20201020-00793
- VernacularTitle:单核苷酸多态性对阿尔茨海默病药物疗效影响的研究进展
- Author:
Minmin ZHAN
1
;
Huixuan MA
;
Xuechun KANG
;
Xinliang LU
;
Shuting GONG
;
Qi ZOU
;
Jianping JIA
;
Cuibai WEI
Author Information
1. 首都医科大学宣武医院神经内科，北京 100053
- Keywords:
Alzheimer disease;
Treatment outcome;
Polymorphism, single nucleotide
- From:
Chinese Journal of Neurology
2021;54(7):723-728
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease is a progressive neurodegenerative disease that requires medication to improve patient symptoms, but there is an individual difference in the efficacy. In this paper, the correlation between single nucleotide polymorphism and the drug efficacy of Alzheimer′s disease (AD) in the past 20 years was searched through the databases of China National Knowledge Infrastructure, VIP Database, Wanfang Database, Pubmed, Springer Link and Cochrane Library with key words of Alzheimer′s disease, drug efficacy, single nucleotide polymorphism. The correlation between AD drug efficacy difference and gene single nucleotide polymorphism was reviewed, including ABCA1, ApoE, ChAT, CHRNA7, IL-6, A2M, CYP2D6, BChE, 5HT2a, PON-1 and ESR1 genes, so as to provide a reference basis for clinicians to select drugs in the treatment of AD.
