A case of limbic encephalitis with positive anti-zinc finger protein 4 antibody and anti-Hu antibody
10.3760/cma.j.cn113694-20210225-00142
- VernacularTitle:抗锌指蛋白4抗体、抗Hu抗体双阳性的边缘性脑炎一例
- Author:
Guangyin XU
1
;
Haitao REN
Author Information
1. 临沂市人民医院神经内科276000
- Keywords:
Autoimmune encephalitis;
Limbic encephalitis;
Anti-ZIC4 antibody;
Anti-Hu antibody
- From:
Chinese Journal of Neurology
2021;54(7):700-704
- CountryChina
- Language:Chinese
-
Abstract:
A case of limbic encephalitis with positive anti-zinc finger protein 4 (ZIC4) antibody and anti-Hu antibody was reported. A middle-aged female was admitted to hospital for two months because of memory loss and unstable walking. The main manifestations were cognitive decline, ataxia and sensory disturbance of both lower extremities. The main diagnosis was limbic encephalitis, complicated with subacute cerebellar degeneration and subacute sensory neuron disease, which was consistent with paraneoplastic nervous system syndrome. Magnetic resonance imaging showed abnormal signals in bilateral temporal lobe and hippocampus, electromyography showed sensory nerve damage, blood and cerebrospinal fluid anti-ZIC4 antibody and Hu antibody were both positive, and no tumor was found. It is speculated that there may be potential tumors and need to be followed up and monitored. This rare case is reported to attract the attention of clinicians.
