Prevention and treatment of Alzheimer′s disease: challenges and perspectives
10.3760/cma.j.cn113694-20210222-00129
- VernacularTitle:阿尔茨海默病防治的挑战与展望
- Author:
Xianle BU
1
;
Binlu SUN
;
Yanjiang WANG
Author Information
1. 陆军军医大学大坪医院（陆军特色医学中心）神经内科，重庆 400042
- Keywords:
Alzheimer disease;
Amyloid-beta;
Tau protein;
Clinical trial;
Prevention;
Treatment
- From:
Chinese Journal of Neurology
2021;54(7):635-639
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease (AD), the most common neurodegenerative disease, is a major challenge in China and all the world. However, the pathogenesis of AD remains unclear, and no disease-modifying therapies are available to prevent or treat the disease. Amyloid-beta (Aβ) and hyperphosphorylated tau protein are key pathological molecules of AD. A series of clinical trials targeting Aβ, tau protein and neuroinflammation have been carried out in the past 20 years, but none of them have been successful in attenuating the cognitive decline so far. This paper discusses the challenges of the current clinical trials of AD and proposes future directions for the research of AD prevention and treatment.
