BRCA gene detection for cancer prevention and management in the high risk population
10.3760/cma.j.cn114798-20210712-00533
- VernacularTitle:BRCA基因在肿瘤预防与高危人群管理中的作用
- Author:
Yaxin XU
1
;
Ru LIU
;
Qizhe WANG
;
Ming LIU
;
Sunfang JIANG
Author Information
1. 复旦大学附属中山医院全科医学科，上海 200032
- Keywords:
Genes, BRCA1;
Genes, BRCA2;
Gene testing;
Neoplasms;
Prevention;
Health management
- From:
Chinese Journal of General Practitioners
2021;20(11):1192-1198
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer susceptibility gene (BRCA) is a tumor suppressor gene. The carriers of BRCA mutation have a significantly higher risk of breast, ovarian, pancreatic, prostate and rectal cancers than the general population. BRCA gene detection can effectively evaluate the risk of relevant malignant tumors. In this article, the recent research progress on the relationship between BRCA gene mutations and related cancers is summarized, and the roles of BRCA gene testing in the prevention and management of relevant malignant tumors are discussed.
