Human parvovirus B19 infection-associated anemia after liver transplantation: three case reports with a literature review
10.3760/cma.j.cn421203-20210121-00038
- VernacularTitle:肝移植后微小病毒B19感染致纯红细胞再生障碍性贫血三例及文献复习
- Author:
Shitao ZHAO
1
;
Yehong YAN
;
Huangbin ZHANG
;
Zide CHEN
;
Chen ZHOU
;
Hao WAN
;
Qi XIAO
;
Jiansheng XIAO
Author Information
1. 南昌大学第一附属医院肝脏外科 330006
- Keywords:
Liver transplantation;
Human parvovirus B19;
Pure red cell aplastic;
Anemia;
Metagenomics
- From:
Chinese Journal of Organ Transplantation
2021;42(11):675-679
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the diagnosis and treatment of pure red cell aplastic anemia (PRCA) caused by parvovirus B19 (HPV-B19)infection after liver transplantation (LT).Methods:Three adult PRCA patients caused by parvovirus B19 infection after LT were reviewed retrospectively.The relevant literatures were collected to sort out the detection methods and treatment of parvovirus B19 infection after LT.Results:All three patients received liver transplantation due to end-stage liver disease with massive intraoperative blood transfusion and smooth postoperative recovery.Severe anemia occurred at 1-2 Months after discharge.Hemorrhagic anemia was excluded after re-admission and PRCA was diagnosed by bone marrow aspiration and next generation sequencing (NGS). After tapering the intensity of immunosuppressive therapy, intravenous immunoglobulin (IVIG) was administered for 7-10 days and hemoglobin soon normalized.A review of 15 recent literatures on HPV-B19 infection after LT revealed that the diagnosis and treatment of parvovirus B19 infection after LT gradually were became same.Conclusions:HPV-B19 infection causes PRCA after LT in adults.Diagnosing with NGS, intravenous injection of immunoglobulin and modification of immunosuppressant regimen may achieve excellent therapeutic efficacies.
