Clinical application of anticoagulation therapy after simultaneous pancreas and kidney transplantation: a single-center observational cohort study
10.3760/cma.j.cn421203-20210410-00127
- VernacularTitle:胰肾联合移植术后抗凝治疗方案的回顾性队列研究
- Author:
Luhao LIU
1
;
Jiali FANG
;
Guanghui LI
;
Lei ZHANG
;
Lu XU
;
Yunyi XIONG
;
Wei YIN
;
Jialin WU
;
Rongxin CHEN
;
Yuhe GUO
;
Junjie MA
;
Zheng CHEN
Author Information
1. 广州医科大学附属第二医院器官移植科 510260
- Keywords:
Pancreas transplantation;
Renal transplantation;
Thrombosis;
Heparin
- From:
Chinese Journal of Organ Transplantation
2021;42(11):663-668
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical efficacy of aspirin plus low molecule heparin for pancreatic thrombosis during simultaneous pancreas and kidney transplantation (SPK).Methods:A total of 129 patients aged 18 years or higher underwent SPK between September 2016 and March 2020.They were divided retrospectively into two groups of aspirin ( n=60) and heparin ( n=69) according to different anticoagulant regimens.The aspirin group received only aspirin 100 mg/d at Day 1 post-operation.The heparin group received subcutaneous injection of enoxaparin 2 000 AxaIU daily for 7 days and followed by aspirin and clopidogrel.Outcomes and complication rates were compared between two groups. Results:All operations were successful without any mortality.In aspirin group, there were 5 cases of pancreatic thrombosis and one patient underwent pancreatectomy.There was no pancreatic thrombosis in heparin group ( P=0.014). There were 8 cases of intestinal anastomotic bleeding in aspirin group and 19 cases in heparin group.Statistically significant inter-group difference existed ( P=0.048). However, no significant inter-group difference existed in delayed recovery or rejection. Conclusions:Heparin anticoagulation can significantly lower the incidence of pancreatic thrombosis after SPK.Despite a higher incidence of intestinal anastomotic bleeding, no serious complication occurs after conservative meaures.
