Application of enhanced recovery after surgery in perioperative period of liver transplantation: a Meta-analysis
10.3760/cma.j.cn421203-20210117-00033
- VernacularTitle:加速康复外科在肝移植围手术期应用的Meta分析
- Author:
Qianqian WU
1
;
Xiuxin FANG
;
Zhen YANG
;
Haibin JI
;
Qiangpu CHEN
Author Information
1. 滨州医学院,山东滨州 256603
- Keywords:
Liver transplantation;
Perioperative period;
Rehabilitation
- From:
Chinese Journal of Organ Transplantation
2021;42(9):544-548
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effectiveness and safety of enhanced recovery after surgery(ERAS)in perioperative period of liver transplantation.Methods:The authors searched systematically domestic and foreign databases to collect researches on applying ERAS for liver transplantation. The retrieval period was from database inception to November 2020. Quality assessment and data extraction were performed by two researchers according to the inclusion criteria. Meta-analysis of postoperative indicators(length of ICU stay, total length of hospital stay, postoperative complications, admission rate & mortality rate)was performed by RevMan 5.3.5 software.Results:3 Three randomized controlled studies (RCTs) and 4 cohort studies were selected with a total of 1 016 patients, including 404 in ERAS group and 612 in conventional group(traditional perioperative management). The results of Meta-analysis revealed that, as compared with control group, length of ICU stay was significantly shorter in ERAS group [weighted mean difference(WMD)=-2.20, 95% CI: -2.43~-1.97, P<0.05]; Total length of hospital stay was significantly shorter in ERAS group [WMD=-5.85, 95% CI: -8.20~-3.49, P<0.05]; The incidence of postoperative complications was significantly shorter in ERAS group [OR=0.61, 95% CI: 0.42~0.88, P<0.05]. However, no inter-group statistically significant differences existed between admission rate or mortality rate( P>0.05). Conclusions:In perioperative period of liver transplantation, using ERAS protocol can shorten length of ICU stay and total length of hospital stay, lower the incidence of postoperative complications and accelerate patient recovery.