Epidemiological survey of invasive pulmonary fungal infection among lung transplant recipients in southern China
10.3760/cma.j.cn421203-20210223-00065-1
- VernacularTitle:华南地区肺移植受者侵袭性肺部真菌感染的调查研究
- Author:
Chunrong JU
1
;
Qiaoyan LIAN
;
Ao CHEN
;
Xin XU
;
Bing WEI
;
Qingdong CAO
;
Wanli LIN
;
Danxia HUANG
;
Shiyue LI
;
Jianxing HE
Author Information
1. 广州医科大学附属第一医院呼吸与危重症科 广州呼吸健康研究院 510120
- Keywords:
Lung transplantation;
Invasive pulmonary fungal infection;
Aspergillus
- From:
Chinese Journal of Organ Transplantation
2021;42(9):539-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the incidence, clinical characteristics and prognosis of invasive pulmonary fungal infection(IPFI)in recipients of lung transplantation(LT)in southern China.Methods:From January 2003 to August 2019, retrospective analysis was performed for 300 recipients of lung transplantation at three hospitals in southern China. There were 254 males and 46 females with an average age of (54.98±14.2)years. Clinical data were collected from medical records, including symptoms and signs, imaging studies, bronchoscopy examination, pathogen separation and culture from deep sputum and bronchoalveolar lavage fluid(BALF), fungal-related laboratory tests and tissue pathology.Results:Among 300 cases, 93(31.0%)had at least one episode of IPFI. The most common pathogen was aspergillosis(60.2%), followed by candida(15 cases, 16.1%)and Pneumocystis jeroveci (13 cases, 14.0%). Kaplan Meier analysis indicated that all-cause mortality was significantly higher in IPFI group than that in non-IPFI(nIPFI)group with one-year mortality of 45.2% vs. 26.7% in IPFI and nIPFI groups respectively( P<0.05). Conclusions:IPFI is prevalent after LT in southern China. And aspergillosis is the most common pathogen and Candida comes the next. The median occurring time for aspergillosis is 6 months after LT. Candida infection occurs earlier at airway anastomosis. A higher incidence of invasive fungal disease(IFD)associated with a lower survival indicates that IPFI has a substantial mortality among recipients after LT. Prophylactic agents should be optimized based upon an epidemiologically likely pathogen.
