Rapidliver autotransplantation by magnetic anastomotic technique during ex situ liver resection in an animal model
10.3760/cma.j.cn421203-20200418-00121
- VernacularTitle:磁吻合技术实现犬离体肝切除肝脏快速无缝线植入的实验研究
- Author:
Shiqi LIU
1
;
Peng LEI
;
Yi LYU
;
Yulong SONG
;
Haohua WANG
;
Jigang BAI
Author Information
1. 西安市儿童医院新生儿外科 陕西省儿科疾病研究所 西安市儿童健康与疾病重点实验室 710043
- Keywords:
Liver autotransplantation;
Vessel;
Magnetic compression anastomosis;
Canine
- From:
Chinese Journal of Organ Transplantation
2021;42(8):485-489
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To invent a set of novel magnetic anastomotic device based upon the technique of magnetic compression anastomosis(MCA)for rapid venous reconstruction during ex situ liver resection, and verify its clinical value and performance in animal models. Methods:Fiften adult mongrel dogs of either gender underwent the ex situ liver resection. The novel magnetic vessel anastomosis device for the venous reconstruction of liver autotransplantation procedure was performed on 8 mongrel dogs(MCA group), and the traditional handsewing technique was used on 5 additional dogs(THS group). Time for completing venous reconstruction and time of venous anastomosis, venous velocity, intraoperative and postoperative survival and complications were recorded. Patency was detected via color Doppler ultrasound scans and X-ray cholangiography after surgery. The changes of intestinal lumen and kidney were also observed. Results:The time required to perform IVC and PV reconstruction for liver autotransplantation was significantly shorter for the magnetic vessel anastomosis device(9.5±2.5) min than for THS(30.7±3.4) min. There was significant difference in anhepatic period( P=0.0000). After operation, except one died, other nine animals in group A survived after operation but all five cases died in the THS group during liver autotransplantation. Vascular X-ray angiography and color Doppler ultrasound found blood flow MCA group normal, and there wasn't stoma stenosis. Conclusions:MCA technique could be fast and efficacious to complete venous reconstruction for liver autotransplantation in ex situ liver resection operation, and helpful to reduce organ ischemia-reperfusion injury.
