Preoperative screening of donors and recipients for living uterine transplantation: an observational study
10.3760/cma.j.cn421203-20200318-00076
- VernacularTitle:活体子宫移植供者与受者术前筛查的观察性研究
- Author:
Tianyi CHENG
1
;
Lianghao ZHAI
;
Li WEI
;
Jiao ZHENG
;
Hong YANG
;
Biliang CHEN
Author Information
1. 空军军医大学第一附属医院妇产科，西安 710032
- Keywords:
Uterine transplantation;
Donor;
Recipient
- From:
Chinese Journal of Organ Transplantation
2021;42(7):426-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize our institutional experiences of screening and selecting potential recipients and living donors for uterine transplantation at a single center.Methods:A total of 102 patients were diagnosed as absolute uterine factor infertility (AUFI). Depending upon the outcomes of previous trials, 8 modules were selected for surveying. A registration form was distributed for subjects at outpatient clinics or through telephone consultations for clinical trials of uterus transplantation between November 2018 and October 2019. The relevant information was collected and entered into a dedicated system for data processing.Results:The number of eligible subjects was 84 and the number of recipients with potential donors 37. The average age of potential recipients was 26.0(18-47) years. Among potential recipients, 76(90.5%) had congenital AUFI and 8(9.5%) acquired AUFI. For potential donors with available organs, the average age was 47.5(32-64) years and the proportion of menopausal or peri-menopausal status 56.8%.Conclusions:Currently large demands and sufficient supports for conducting clinical trials of uterine transplantation are available in China. However, inherent deficiencies persist in organ donor population reserves and preoperative screening protocols, such as donor age and subjective/objective factors of participants. During clinical trials of uterine transplantation, preoperative screening should be performed for expanding the screening scope, extending the screening time and popularizing the screening knowledge to boost the success rate.
