Medium-term outcomes of kidney transplantation from old-aged deceased donors: a single-center retrospective analysis
10.3760/cma.j.cn421203-20210219-00062
- VernacularTitle:老年供肾移植的中期效果分析
- Author:
Qian HUANG
1
;
Huibo SHI
;
Xia LU
;
Sheng CHANG
;
Dunfeng DU
;
Lan ZHU
;
Weijie ZHANG
;
Changsheng MING
;
Bin LIU
Author Information
1. 华中科技大学同济医学院附属同济医院器官移植研究所 教育部器官移植重点实验室 国家卫生健康委员会器官移植重点实验室 中国医学科学院器官移植重点实验室，武汉 430030
- Keywords:
Kidney transplantation;
Elderly donated kidney;
Evaluation
- From:
Chinese Journal of Organ Transplantation
2021;42(6):344-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the medium-term outcomes of single kidney transplantation from senile deceased donors aged above 65 years.Methods:Forty-three kidney recipients from donors aged above 65(old-aged donor group, OAD) and 43 kidney recipients of the same age and gender from donors aged 18 to 49 years(standard-criteria donor group, SCD) were retrospectively reviewed.The survival outcomes of patients and grafts, renal functions, the incidence of delayed graft function(DGF)and other complications were recorded within the 3-year follow-up post-transplantation.Results:The 3-year patient survival rates were 95.3% both in OAD and SCD and the 3-year death-censored graft survival rates 92.7% and 97.6% respectively.The serum levels of creatinine were significantly higher in OAD than that in SCD( P<0.05). And lower estimated glomerular filtration rate(eGFR)was found in OAD as compared with SCD( P<0.05). No significant difference existed in the incidence of DGF(OAD 20.9% and SCD 18.6%, P>0.05), acute rejection (OAD 4.7% and SCD 2.3%, P>0.05)or proteinuria(OAD 27.9%and SCD 14.0%, P>0.05). Conclusions:Single kidney transplantation from old-aged deceased donors may achieve excellent medium-term survival outcomes of patients and grafts.It can expand the donor pool though kidney functions were not as good as those of SCD.
