Effect of continuous intravenous infusion of low-dose heparin on preventing thrombosis during perioperative period of simultaneous pancreas-kidney transplantation
10.3760/cma.j.cn421203-20191017-00375
- VernacularTitle:小剂量肝素静脉持续泵入预防胰肾联合移植术后血栓形成
- Author:
Meisi LI
1
;
Jianhui DONG
;
Pengfei QIAO
;
Jihua WU
;
Ke QIN
;
Liugen LAN
;
Hongliang WANG
;
Zhuangjiang LI
;
Haibin LI
;
Zhao GAO
;
Xuyong SUN
Author Information
1. 中国人民解放军联勤保障部队第九二三医院器官移植科 广西移植医学重点实验室 广西移植医学工程技术研究中心，南宁 530021
- Keywords:
Pancreas transplantation;
Simultaneous pancreas and kidney transplantation;
Heparin
- From:
Chinese Journal of Organ Transplantation
2021;42(4):234-238
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of continuous infusion of low-dose intravenous (Ⅳ) heparin during perioperative period of simultaneous pancreas-kidney (SPK) transplantation for donation after citizen death (DCD) donor to prevent pancreatic thrombosis post-transplantation.Methods:From January 2015 to August 2019, 46 DCD donors undergoing SPK were divided into retrospective cohort groups 1 ( n=27) and 2 ( n=19). Group 1 received aspirin enteric-coated tablets only at Day 1 post-SPK. In Group 2, 5-7 days of continuous infusion of heparin 260 IU per hour at Day 1 post-SPK was followed by a daily intake of aspirin enteric-coated tablets of 100 mg. Incidence of thrombus, recovery of graft function and adverse reactions of anticoagulant therapy were observed. Results:Thrombosis occurred in (5.3%, 1/19 vs 14.8%, 4/27) in heparin and non-heparin groups. Thrombosis and graft loss were significantly lower in heparin group than those in non-heparin group ( P<0.05). Conclusions:Continuous infusion of low-dose heparin vein is effective and safe in preventing thrombosis after SPK transplantation.
