Recurrence and prognosis of hepatocellular carcinoma after liver transplantation in different age qronps
10.3760/cma.j.cn421203-20210204-00050
- VernacularTitle:不同年龄组肝癌肝移植受者术后复发和预后评价
- Author:
Bo ZHANG
1
;
Bo LI
;
Tianfu WEN
;
Hong WU
;
Wentao WANG
;
Li JIANG
;
Jiayin YANG
Author Information
1. 四川大学华西医院器官移植中心，成都 610041
- Keywords:
Liver transplantation;
Hepatic cell carcinoma;
Survival rate
- From:
Chinese Journal of Organ Transplantation
2021;42(3):141-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the long-term prognosis and recurrence of young liver transplant recipients with hepatocellular carcinoma(HCC).Methods:Based upon the database of liver transplantation center, clinical data were retrospectively reviewed for 39 young recipients(18~40 years)and 158 middle-aged and elderly recipients(over 40 years)from 2013 to 2017. The parameters of overall survival(OS), recurrence-free survival(RFS)and disease-specific survival(DSS)were compared between two groups.Cox's proportional hazard model was utilized for evaluating the prognostic factors.Results:Significant inter-group difference existed in recurrence rate of HCC. Kaplan-Meier analysis revealed no significant difference in OS rate(1/3-year OS, 82.1%, 66.7% and 86.1%, 74.7%, P>0.05)and DSS rate(1/3-year DSS, 94.9%, 82.1% and 99.4%, 91.1%, P=0.053); RFS rate(1/3-year RFS, 51.3%, 41.0% and 73.0%, 62.7%, P=0.008)showed significant differences; Cox multivariate analysis revealed that AFP>400 μg/L was an independent risk factor for OS, DSS and RFS; poorly differentiated tumors and positive micro-vascular invasion(MVI)were independent risk factor for DSS; poorly differentiated tumors and total tumor size >5 cm were independent risk factors for RFS. Conclusions:Although RFS of young adult group is worse than that in middle-aged and elderly group after LT, no significant inter-group difference exists in OS or DSS. And LT is still a quite effective treatment for young HCC patients.
