The predictive value of circulating tumor cells count in portal vein blood on the postoperative prognosis of patients with pancreatic cancer
10.3760/cma.j.cn113855-20210310-00150
- VernacularTitle:门静脉血循环肿瘤细胞计数对胰腺癌根治性切除术患者预后的预测价值
- Author:
Yujin PAN
1
;
Lianyuan TAO
;
Ning WANG
;
Guangjin TIAN
;
Erwei XIAO
;
Haibo YU
;
Deyu LI
Author Information
1. 郑州大学人民医院肝胆胰腺外科 450003
- Keywords:
Pancreatic neoplasms;
Prognosis;
Circulating tumor cells;
Portal vein blood
- From:
Chinese Journal of General Surgery
2021;36(11):826-830
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of portal vein (PoV) blood circulating tumor cells (CTCs) count in patients with pancreatic cancer on the postoperative prognosis.Methods:The data of 58 patients receiving radical resection of pancreatic cancer and PoV CTCs detection at People's Hospital of Zhengzhou University from Aug 2018 to Jun 2020 were collected. According to the cut-off value of PoV CTCs>10/5 ml made by receiver operating characteristic curve (ROC), patients were divided into high CTCs group and low CTCs group and the differences in clinicopathological parameters and prognosis of the two groups were compared.Results:Postoperative progression-free survival rate of the low CTCs group was higher than that of the high CTCs group ( χ 2=12.97, P<0.001).Univariate COX regression analysis showed that tumor diameter >4 cm, lymph node invasion, TNM staging, CTCs>10/5 ml, postoperative CA199>37 U/m were risk factors for postoperative prognosis. Multivariate COX regression analysis demonstrated that TNM stage ( OR=2.782, P=0.024), CTCs count >10/5 ml ( OR=2.583, P=0.047), postoperative CA199>37 U/m ( OR=3.775, P=0.004) were the independent risk factors of prognosis. Conclusion:A higher PoV CTCs count was a risk factor for poor prognosis of patients with pancreatic cancer after radical resection.
