Expression of CDK5 and its correlation with peripheral inflammation-related cells and prognosis in colon cancer patients
10.3760/cma.j.cn113855-20210407-00226
- VernacularTitle:CDK5在结肠癌组织中的表达及其与患者外周血炎症相关细胞及预后的关系
- Author:
Qinghua WANG
1
;
Ruihua YIN
;
Bin HU
;
Bingjing JIANG
;
Zhihui DAI
;
Wanfen TANG
;
Xia ZHANG
;
Shishi ZHOU
;
Jianfei FU
Author Information
1. 浙江大学医学院附属金华医院肿瘤内科，浙江省 321000
- Keywords:
Colonic neoplasms;
Cyclin dependent kinase 5;
Leukocyte;
Prognosis
- From:
Chinese Journal of General Surgery
2021;36(10):774-778
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify the clinical significance of CDK5 in colon cancer tissues.Methods:Two hundred colon cancer tissues were tested for CDK5 expression by immunohistochemistry on tissue microarrays. The correlation between CDK5 expression and clinicopathological features, prognosis and peripheral inflammation-related cells was analyzed.Results:CDK5 was low expressed in 100 cases (50.0%), and high in another 100 cases (50.0%). Longer time to tumor progression ( P=0.026) and overall survival ( P=0.035) were observed in patients with high CDK5 expression. By multivariate analysis , the expression of CDK5 was an independent risk factor for poor prognosis ( HR=0.45,95% CI: 0.21-0.99, P=0.049). The expression of CDK5 was not related to the counts of white blood cells and neutrophils ( P>0.05). Prognosis of patients with a positive lymph node ratio less than 0.15 was significantly better than that of patients with a higher lymph node ratio ( P<0.001). Conclusions:Patients with low CDK5 expression have poor prognosis, and CDK5 expression is not related to the counts of peripheral white blood cells and neutrophils.
