Clinicopathological risk factors of retroperitoneal liposarcoma recurrence-free survival after surgical resection
10.3760/cma.j.cn113855-20210401-00212
- VernacularTitle:腹膜后脂肪肉瘤术后复发因素分析
- Author:
Aobo ZHUANG
1
;
Qian WU
;
Jiongyuan WANG
;
Jing XU
;
Hanxing TONG
;
Yong ZHANG
;
Weiqi LU
Author Information
1. 上海市(复旦大学附属)公共卫生临床中心普外科 复旦大学附属中山医院南院普外科，上海 201508
- Keywords:
Liposarcoma;
Retroperitoneal neoplasms;
Recurrence;
Prognosis
- From:
Chinese Journal of General Surgery
2021;36(10):766-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinicopathological risk factors of retroperitoneal liposarcoma recurrence-free survival after surgical resection, and establish a prediction model based on clinicopathological risk factors.Methods:We conducted a retrospective analysis for retroperitoneal liposarcoma patients undergoing surgical resection at Department of General Surgery, Shanghai Public Health Clinical Center, Zhongshan Hospital (South), Fudan University, during Jul 2014 and Jun 2020. The clinical and pathological data were collected. Univariate and multivariate analysis were used to select independent risk factors.Result:A total of 271 patients were included, and 127 (46.9%) were recurred. In the recurrence group, more patients were assessed as recurrent disease ( χ2=15.289, P<0.05), the proportion of tumors invading organs was higher ( χ2=10.123, P<0.05), and FNCLCC graded higher ( χ2=7.650, P<0.05). The median follow-up time for all patients was 25 months (1-58 months). The 1, 2, and 3-year recurrence-free survival rates were 61.4%, 40.3%, and 30.9%, respectively. Univariate analysis suggests that recurrent disease, organ invasion, poorly differentiated pathological types, and high FNCLCC grades are poor prognostic factors for postoperative recurrence (all P<0.05); Multivariate analysis showed that recurrent disease ( OR=3.135, 95% CI: 2.058-4.762, P<0.05), organ invasion ( OR=2.577, 95% CI: 1.214-5.464, P<0.05) and high FNCLCC grade ( P<0.05) is an independent prognostic factor for postoperative recurrence. Conclusion:Presentation status,FNCLCC grade and organ invasion were independent risk factors for retroperitoneal liposarcoma recurrence after surgery.
