Correlation between clinicopathologic features and BRAF V600E gene mutation abundance in papillary thyroid carcinoma

VernacularTitle:BRAF V600E基因突变丰度与甲状腺乳头状癌临床病理学特征的关系
Author: Yong ZHAO ¹ ; Bo GAO ; Zhuomiaoyu CHEN ; Qiusheng WANG
Author Information

1. 北京大学人民医院腔镜普通外科　100044
Keywords: Thyroid neoplasms; Carcinoma, papillary; Gene mutation; Pathology, clinical
From: Chinese Journal of General Surgery 2021;36(9):684-686
CountryChina
Language:Chinese
Abstract: Objective:To investigate the correlation between cervical lymph node metastasis,extra thyroidal extension and other clinicopathologic features and BRAF V600E gene mutation abundance in papillary thyroid carcinoma. Methods:The clinicopathologic data of 123 PTC patients admitted from Jan 2018 to Oct 2020 in Peking University People's Hospital were analyzed retrospectively. All the PTC cases were examined by next generation sequencing technology. BRAF V600E gene mutation abundances were detected and analyzed with different clinicopathologic features, and differences between groups were compared. Results:There were statistical differences compared to control group in BRAF V600E gene mutation abundances in lymph node metastasized group and extra thyroidal extended group(all P<0.05). BRAF V600E gene mutation abundances were positively related with severity of extra thyroidal extension( P<0.05). Conclusion:BRAF V600E gene mutation abundance was related with cervical lymph node metastasis and extra thyroidal extension in PTC patients.