Expression of vasohibin-1 and VEGF-A and its clinical significance in gastric cancer
10.3760/cma.j.cn113855-20210311-00152
- VernacularTitle:血管生成抑制因子l和血管内皮生长因子A在胃癌组织中的表达及其临床意义
- Author:
Yichao YAN
1
;
Chao SHEN
;
Ning NING
;
Yankai ZHANG
;
Wenyue WANG
;
Yingjiang YE
;
Shan WANG
Author Information
1. 北京大学国际医院胃肠外科 102206
- Keywords:
Stomach neoplasms;
Neoplasm invasion;
Neoplasm metastasis;
Prognosis
- From:
Chinese Journal of General Surgery
2021;36(8):612-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression of vasohibin-1 (VASH1) and vascular endothelial growth factor A (VEGF-A) and clinical significance of VASH1 in gastric carcinoma.Methods:The expression of VASH1 and VEGF-A were detected by immunohistochemistry in formalin-fixed and paraffin-embedded sections in 56 pairs of gastric cancer and corresponding paraneoplastic tissue specimens. The correlation between the expression of VASH1, VEGF-A, clinicopathological parameters and prognosis were analyzed.Results:VASH1 and VEGF-A expression was significantly higher in gastric cancer tissues than normal paraneoplastic tissues. VASH1 and VEGF-A protein were expressed in 79% and 82% of gastric cancer tissues, respectively. A positive correlation was found between Vasohibin-1 and VEGF-A expression in gastric cancer tissues. VASH1 expression has significant positive correlation with TNM stage, tumor stromal invasion, tumor gross types and distant metastasis. Patients with high VASH1 expression had significantly worse overall survival (OS) and progression-free survival (PFS) than those with low VASH1 expression.Conclusion:VASH1 might be a clinically relevant predictor of patients in gastric cancer.
