Liver regeneration after hemihepatectomy in patients with HBV-related hepatocellular carcinoma
10.3760/cma.j.cn113855-20200520-00403
- VernacularTitle:乙肝病毒相关性肝细胞癌患者行半肝切除术后肝再生的临床研究
- Author:
Chuan LI
1
;
Zhan LU
;
Wenfeng GONG
;
Bangde XIANG
;
Jianhong ZHONG
;
Lequn LI
Author Information
1. 广西医科大学附属肿瘤医院肝胆胰脾外科，南宁 530021
- Keywords:
Carcinoma, hepatocellular;
Hepatectomy;
Liver regeneration
- From:
Chinese Journal of General Surgery
2021;36(7):507-511
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical impact factors of liver regeneration after hemihepatectomy in patients with hepatocellular carcinoma (HCC).Methods:Patients who underwent hemihepatectomy due to HCC from Sep 2013 to Sep 2018 were included in the study. Liver volumes were calculated by perioperative simulations to analyze the influencing factors of postoperative liver regeneration, and to compare the albumin bilirubin (ABLI) score and the end-stage liver disease (MELD) score at weeks 1, 5, 9, and 13 after operation.Results:A total of 163 patients were included, of which 13 developed postoperative liver failure. The median liver regeneration rates at 1, 5, 9 and 13 weeks after operation were 22.0%, 32.2%, 33.7% and 35.4%, respectively. Multivariate analysis showed that remnant liver volume (RLV) <611.1 cm 3, %RLV and liver cirrhosis were the influencing factors of liver regeneration. ALBI score and MELD score were lower in the low regeneration group compared to the high regeneration group in the first 5 weeks after operation. Conclusion:RLV and cirrhosis are influential factors in postoperative liver regeneration. Liver regeneration proceeded rapidly within 1 week and slowed down until week 5.
