Tumor budding is related with clinicopathology and prognosis of pancreatic neuroendocrine tumors
10.3760/cma.j.cn113855-20200527-00425
- VernacularTitle:肿瘤出芽与胰腺神经内分泌瘤临床病理的相关性及预后价值分析
- Author:
Yuanxiang LU
1
;
Wensen LI
;
Erwei XIAO
;
Lianyuan TAO
;
Senmao MU
;
Yafeng WANG
;
Liancai WANG
;
Deyu LI
Author Information
1. 郑州大学人民医院/河南省人民医院肝胆胰腺外科 郑州450003
- Keywords:
Pancreatic neoplasms;
Neoplasm metastasis;
Prognosis;
Tumor budding
- From:
Chinese Journal of General Surgery
2021;36(7):494-498
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of tumor budding in the clinicopathology and prognosis of pancreatic neuroendocrine tumors.Methods:The Cliniccal data of 105 pancreatic neuroendocrine tumor patients underwent resection in Henan Provincial People's Hospital from Jan 2010 to Dec 2016 were retrospectively analyzed. Tumor budding was calculated through hematoxylin-eosin (HE) and immunohistochemical stained slides. Based on the receiver operating characteristic curve (ROC), the number of tumor budding ≥10 was defined as the high-grade budding group, and <10 as the low-grade budding group. Multiple analysis was performed to determine the relationship between tumor budding and clinicopathology as well as prognosis.Results:High-grade budding group was observed in 35 cases and low-grade group in 70. High-grade budding were more common in tumors with advanced T stage, high risk of lymphatic metastasis, preoperative liver metastasis, vascular invasion and postoperative recurrence (respectively χ 2=9.043, 4.286, 10.130, 12.090, 9.260, all P<0.05). Multivariate COX regression analysis showed that tumor budding ( P=0.018), tumor grade ( P=0.026), preoperative liver metastasis ( P=0.042), vascular invasion( P=0.048) was independent risk factors predicting poor prognosis. Conclusion:Tumor budding is highly correlated with clinicopathological parameters which reflect the aggressiveness of pancreatic neuroendocrine tumor, it is also an important prognostic factor.
