Role of immunoglobulin E autoantibodies in autoimmune skin diseases
- VernacularTitle:免疫球蛋白E型自身抗体在自身免疫相关皮肤病中的研究进展
- Author:
Gaopeng LIANG
1
;
Zhiqiang SONG
Author Information
- Keywords: Immunoglobulin E; Autoimmune diseases; Lupus erythematosus, systemic; Pemphigoid, bullous; Chronic idiopathic urticaria; IgE autoantibodies
- From: Chinese Journal of Dermatology 2021;54(6):553-556
- CountryChina
- Language:Chinese
- Abstract: A large number of studies have shown that immunoglobulin E (IgE) not only participates in the occurrence and development of allergic reactions, but also induces and aggravates autoimmune reactions through various mechanisms. IgE autoantibodies have been confirmed to be present in a variety of autoimmune skin diseases, and may be involved in the occurrence and development of related diseases by affecting multiple immune cells such as dendritic cells, mast cells, and basophils via binding to autoantigens. This review summarizes the role and possible mechanism of action of IgE in the induction and exacerbation of autoimmune skin diseases such as systemic lupus erythematosus, bullous pemphigoid and chronic idiopathic urticaria, and provides a theoretical basis for clinical diagnosis and treatment.
