Effects of orlistat and metformin on metabolism and gonadal function in overweight or obese patients with polycystic ovary syndrome
10.3760/cma.j.cn112138-20210302-00171
- VernacularTitle:奥利司他和二甲双胍对超重或肥胖多囊卵巢综合征患者代谢及性腺功能的影响
- Author:
Yuxing ZHAO
1
;
Linjie WANG
;
Fengying GONG
;
Hui PAN
;
Hui MIAO
;
Lian DUAN
;
Hongbo YANG
;
Huijuan ZHU
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院内分泌科 国家卫生健康委员会内分泌重点实验室 疑难重症及罕见病国家重点实验室 100730
- Keywords:
Polycystic ovary syndrome;
Orlistat;
Metformin
- From:
Chinese Journal of Internal Medicine
2021;60(12):1165-1168
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to assess the effects of orlistat or metformin treatment on lipid and glucose metabolism, and gonadal function in obese/overweight women with polycystic ovary syndrome (PCOS). A total of 39 patients diagnosed with PCOS were randomly (digital table method) divided into orlistat treatment group (20 cases) and metformin treatment group (19 cases). Compared with those before, treatment with either orlistat or metformin significantly reduced body weight, body mass index (BMI), hip circumferences, and serum insulin levels of the PCOS patients both at the end of 3 months and 6 months ( P<0.05). No significant differences could be viewed between orlistat and metformin treated subjects. Moreover, orlistat treatment significantly lowered the levels of low-density lipoprotein cholesterol, total cholesterol, fasting blood glucose, and homeostasis model assessment-insulin resistance (HOMA-IR) ( P<0.05), while there were no significant changes in above parameters with metformin treatment. The improvement of menstrual cycle was observed after 6-month treatment in both groups ( P<0.05). However, changes in polycystic ovarian morphology by ultrasound were only observed in orlistat treated group. In conclusion, orlistat is comparable with metformin in weight loss and improvement of insulin resistance and menstrual cycle, and is superior to metformin in improvement of lipid metabolism in overweight/obese PCOS patients.
