The effects of liraglutide on body composition and muscle strength in adult obese patients with type 2 diabetes mellitus
10.3760/cma.j.cn112138-20210205-00105
- VernacularTitle:利拉鲁肽对成年肥胖2型糖尿病患者身体成分和肌力的影响
- Author:
Dongni YU
1
;
Lijuan WANG
;
Bo CHENG
;
Miao LI
;
Qi PAN
;
Lixin GUO
Author Information
1. 北京医院内分泌科 国家老年医学研究中心 中国医学科学院老年医学研究院100730
- Keywords:
Diabetes mellitus, type 2;
Obesity;
Body composition;
Muscle strength;
Lilarutide
- From:
Chinese Journal of Internal Medicine
2021;60(11):982-986
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The aim of the present study was to observe the effects of liralutide on body composition and muscle function in adult obese patients with type 2 diabetes.Method:A total of 63 adult obese type 2 diabetic patients who were (52.6±9.7) years of age and with body mass index (BMI) of ≥28 kg/m 2 were enrolled. The patients were randomly assigned into two groups. On the basis of maintaining the original hypoglycemic regimen, patients in the control group ( n=24) were given dietary guidance only, and those in the treatment group ( n=39) were injected with liraglutide. All patients were followed up for a period of 12 weeks. Blood glucose, glycosylated hemoglobin(HbA1c) and insulin levels, liver and kidney function, body composition assessed with electrical impedance methods, and grip strength measured by a grip meter for muscle function were detected at the baseline and the end of the study. Results:Compared with those in the control group, the reductions in HbA1c [(-1.54±2.10) % vs.(-0.53±0.84) %], body weight [(-3.46±4.2) kg vs.(-0.34±3.66) kg], body fat mass [(-1.97±2.98) kg vs.(-0.01±2.16) kg] and visceral fat area [(-0.01±2.16) cm 2 vs.(0.34±6.39) cm 2] were more pronouced in liraglutide treated group (all P<0.05). However, no changes could be observed in muscle mass and grip strength after liraglutide treatment. Conclusions:In addition to reducing blood glucose, body weight and fat mass, treatment with lilaluptide had no impact on muscle mass and muscle function. Therefore, liralutide is suitable for obese patients with type 2 diabetes, especially for weight management patients who are at risk of muscle loss.
