Effectiveness and safety of ultrasound-guided microwave ablation for the treatment of primary hyperparathyroidism in 12 patients with parathyroid adenoma
10.3760/cma.j.cn112138-20201111-00935
- VernacularTitle:超声引导下微波消融治疗12例原发性甲状旁腺功能亢进症的疗效及安全性
- Author:
Wenjing NI
1
;
Xiaoqiu CHU
;
Chenya LU
;
Guofang CHEN
;
Xue HAN
;
Yang XU
;
Xinping WU
;
Jianhua WANG
;
Chao LIU
;
Shuhang XU
Author Information
1. 南京中医药大学附属中西医结合医院内分泌科210028
- Keywords:
Hyperparathyroidism, primarys;
Microwave ablation
- From:
Chinese Journal of Internal Medicine
2021;60(10):904-907
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effectiveness and safety of ultrasound-guided microwave ablation (MWA) in treatment of primary hyperparathyroidism (PHPT). A total of 12 PHPT patients with parathyroid adenoma were treated with MWA in Nanjing University of Chinese Medicine Affiliated Hospital of Integrated Traditional Chinese and Western Medicine from May 2019 to February 2021. The patients were followed up once every 3 months for 3-12 months. Levels of serum parathyroid hormone (PTH), calcium and phosphorus were detected before and 20 min, 4h and 1day after ablation, and during follow-up period. The volume and volume reduction rate of parathyroid lesion were compared before the treatment and at the end of follow-up. The technical and clinical success of MWA were assessed as well. At the end of follow-up, median serum PTH [66.60 (42.21,80.03) ng/L vs.169.90 (89.01,396.50) ng/L] and calcium [2.39 (2.32,2.49) mmol/L vs. 2.75 (2.57,2.96) mmol/L] levels in 12 patients decreased significantly (all P<0.05). A complete response in terms of PTH and calcium levels was achieved in 6 of the 12 patients, while 4 of the patients had slightly elevated PTH levels just above the upper limit of normal reference range, and 2 of the patients remained abnormal PTH and calcium levels. The clinical cure rate was 50%. The volumes of all lesion after ablation were significantly decreased ( P<0.05), with the technical success rate reaching 92.3%. No serious complications were observed. Ultrasound-guided MWA, thus, is safe and effective in the treatment of PHPT.
