Correlation of serum lipid profile and disease activity in patients with inflammatory bowel disease
10.3760/cma.j.cn112138-20200930-00847
- VernacularTitle:炎症性肠病患者血脂水平与疾病活动的相关性分析
- Author:
Di WANG
1
;
Xiaojing ZHAO
;
Xiufang CUI
;
Linzhen LI
;
Hongjie ZHANG
Author Information
1. 南京医科大学第一附属医院消化科 210029
- Keywords:
Crohn disease;
Colitis, ulcerative;
Dyslipidemias
- From:
Chinese Journal of Internal Medicine
2021;60(9):834-836
- CountryChina
- Language:Chinese
-
Abstract:
To analyze the correlation between lipid profile and disease activity in patients with inflammatory bowel disease (IBD).A total of 307 Crohn′s disease (CD) patients, 232 ulcerative colitis (UC) patients and 165 healthy subjects from the same geographic region were included. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a)[Lp(a)] were retrieved from their medical records. Crohn disease activity index (CDAI) and Mayo scores were calculated as measurement of disease severity for CD and UC separately. Patients with CD and UC had lower TC, TG, HDL-C and LDL-C levels than those in control group ( P<0.05). Additionally, CDAI was negatively associated with TC, HDL-C and LDL-C levels ( r=-0.218, -0.210, -0.176, P<0.05), while TG level was not associated with CDAI. Mayo scores was not significantly associated with TC, HDL-C, LDL-C and TG. Patients with CD had higher Lp(a) levels than those in UC and control group ( P<0.05). Furthermore, patients with active CD had higher Lp (a) levels than those with inactive disease ( P<0.05).The Lp(a) levels in CD patients were positively associated with CDAI ( r=0.151, P<0.05), while Lp(a) level in UC group was nor assocriated with Mayo score. Patients with IBD have dyslipidemia and lipid profile is associated with disease activity in CD patients.
