Clinical analysis of left atrial appendage occlusion for stroke prevention in elderly patients with atrial fibrillation
10.3760/cma.j.cn112138-20201202-00985
- VernacularTitle:左心耳封堵术用于老年心房颤动患者卒中预防的临床分析
- Author:
Wenli DAI
1
;
Ran YANG
;
Pengfei GUO
;
Chao JIANG
;
Yiwei LAI
;
Yan ZHANG
;
Jiahui WU
;
Xu LI
;
Songnan LI
;
Rong BAI
;
Xin DU
;
Jianzeng DONG
;
Changsheng MA
Author Information
1. 国家心血管疾病临床医学研究中心 首都医科大学附属北京安贞医院心内科 100029
- Keywords:
Left atrial appendage occlusion;
Atrial fibrillation;
Elderly;
Stroke
- From:
Chinese Journal of Internal Medicine
2021;60(9):822-826
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the efficacy and safety of left atrial appendage occlusion (LAAO) in patients with atrial fibrillation (AF) over 75 years. A total of 82 patients with AF who underwent LAAO successfully in Beijing Anzhen Hospital from March 2014 to March 2019 were divided into two groups according to age: the elderly group (aged>75 years) and the young group (aged ≤75 years). Risk of perioperative complications and incidence of ischemic stroke and major bleeding during follow-up were retrospectively analyzed. The results showed that there were no significant differences in procedure-related ischemic stroke(0 vs.1.6%, P=0.768) and major bleeding (0 vs.1.6%, P=0.768) during perioperative period between the two groups. No complications as death or pericardial tamponade occurred in the two group. During a (25.9±15.9) months period of followed up, ischemic stroke event rate was 3.6/100 person-years in the elderly group and 4.9/100 person-years in the young group, respectively. Major bleeding event rate was 2.5/100 person-years in the elderly group and 0/100 person-years in the young group, respectively. Compared with the expected ones, the relative risk reduction (RRR) of stroke in the elderly group was more profound than that in the young group (32.0% vs. 25.0%), while the risk of major bleeding in the young group was significantly lower than that in the elderly group (RRR 100% vs. 56.9%). Therefore, LAAO might be suitable for stroke prevention in the elderly AF patients.
