The prognostic factors of extramedullary relapse after allogeneic hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia
10.3760/cma.j.cn112138-20200729-00717
- VernacularTitle:急性淋巴细胞白血病异基因造血干细胞移植后髓外复发的影响因素和预后分析
- Author:
Linyao ZHANG
1
;
Jian ZHOU
;
Binglei ZHANG
;
Yingling ZU
;
Yanli ZHANG
;
Fengkuan YU
;
Yongping SONG
Author Information
1. 郑州大学附属肿瘤医院血液科，郑州 450003
- Keywords:
Hematopoietic stem cell transplantation;
Leukemia;
Extramedullary relapse;
Allogeneic
- From:
Chinese Journal of Internal Medicine
2021;60(8):757-759
- CountryChina
- Language:Chinese
-
Abstract:
To analyze the prognostic factors of extramedullary relapse (EMR) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in acute lymphoblastic leukemia (ALL).The clinical data of 33 relapsed patients in 95 ALL patients receiving allo-HSCT were analyzed retrospectively. The median time of relapse was 5.7 (0.7-52.3) months. Extramedullary relapse was recorded in 10 cases (10.5%), bone marrow relapse in 15 cases (15.8%), and both extramedullary and marrow relapse were seen in 8 cases (8.4%). The median time of EMR was 7.4(0.7-52.3) months. The most commonly involved organ was central nervous system, followed by testis and bone. The 3-year OS rate in EMR patients was (33.3±11.1) %. Univariate analysis showed that disease state before transplantation ( P=0.026), extramedullary infiltration before transplantation ( P=0.005), conditioning regimens ( P=0.033) and acute graft-versus-host disease(aGVHD) ( P=0.013) were significantly correlated with EMR. Multivariate analysis suggested that extramedullary infiltration ( RR=5.067, 95 %CI1.542-16.645, P=0.007) and aGVHD( RR=3.585, 95 %CI1.245-10.320, P=0.018) were independent predictive factors of EMR in ALL patients after allo-HSCT.
