The prediction of disease progression by 18Fluorodeoxyglucose-positron emission computed tomography/CT in patients with dermatomyositis and interstitial lung disease
10.3760/cma.j.cn112138-20201119-00954
- VernacularTitle:18F脱氧葡萄糖-正电子发射断层扫描/CT对预测皮肌炎肺间质病变进展的研究
- Author:
Zheng ZHAO
1
;
Kunpeng LI
;
Yanyan WANG
;
Lei PEI
;
Zhiwei GUAN
;
Jingyu JIN
;
Jian ZHU
;
Jianglin ZHANG
;
Feng HUANG
Author Information
1. 解放军总医院第一医学中心风湿免疫科，北京 100853
- Keywords:
Dermatomyositis;
Lung diseases, interstitial;
[ 18F]fluorodeoxyglucose- positron emission computed tomography/CT
- From:
Chinese Journal of Internal Medicine
2021;60(7):661-664
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the predictive value of [ 18F]fluorodeoxyglucose-positron emission computed tomography(PET)/CT for disease progression in patients with dermatomyositis (DM) and interstitial lung diseases (ILD). Sixty-seven DM patients who underwent [ 18F] FDG-PET/CT imaging were retrospectively analyzed from January 2012 to September 2017 at PLA General Hospital. Their clinical manifestations and imaging characteristics were recorded. Compared with those chronically progressed (C-ILD), patients with rapid progression (RP-ILD) had significantly higher erythrocyte sedimentation rate (ESR) and standardized uptake value (SUV) in lungs ( P<0.05). In patients with RP-ILD, SUV in lungs was positively correlated with age, disease course, and ESR. Receiver operating characteristic curve analysis suggested that when lung SUV cut off value was 2.25, the sensitivity and specificity to predict disease progression was 77.8% and 72.8%, respectively. Old age, longer disease course, low creatine kinase level, higher ESR, and high SUV are prognostic factors for DM-associated ILD.
