The combination of YAP/TAZ predicts the clinical prognosis in patients with cholangiocarcinoma after radical resection
10.3760/cma.j.cn112138-20210201-00091
- VernacularTitle:YAP/TAZ联合应用对预测胆管癌根治性切除术后患者预后的价值分析
- Author:
Ying LIU
1
;
Ying WU
;
Yushu OUYANG
;
Jingjing HE
;
Lujun SHEN
;
Han QI
;
Fei CAO
;
Shuanggang CHEN
Author Information
1. 广州中医药大学金沙洲医院国际肿瘤医疗中心放疗科 510060
- Keywords:
Cholangiocarcinoma;
Prognosis;
YAP/TAZ
- From:
Chinese Journal of Internal Medicine
2021;60(7):637-643
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Cholangiocarcinoma (CCA) is a malignant tumor derived from bile duct epithelial cells with extremely poor prognosis. The Hippo-Yes-associated protein (YAP)/transcription activator with PDZ binding motif (TAZ) signaling plays a critical role in cancer stem cell biology. Previous studies have shown that the positive expression of YAP/TAZ in CCA predicts larger tumor size and unfavorable clinical outcomes. We aim to evaluate the prognostic value of YAP/TAZ detection in CCA patients.Methods:CCA patients who underwent radical resection were retrospectively analyzed at our institution from January 2011 to June 2016. Postoperative pathological specimens were scored by YAP/TAZ immunohistochemical staining. The prognostic value of YAP/TAZ was analyzed by multivariate Cox-proportional hazards model.Results:A total of 91 CCA patients were enrolled. During a median follow-up time of 11.0 months, 69.2% patients relapsed and 45.1% died. The median OS and DFS were 10.7 months and 8.8 months respectively. The YAP/TAZ dual positive patients owned a worse TNM stage ( P=0.015), poorer tissue differentiation ( P=0.007), and a higher CA199 than those in negative patients. Multivariate Cox analysis identified that YAP/TAZ dual positivity as a significant factor predicted poorer OS ( P=0.010) and DFS ( P=0.028) in CCA patients after radical resection. In subgroup analysis, YAP/TAZ combination also significantly predicted OS ( P=0.044) and DFS ( P=0.043) in CCA patients with positive lymphatic metastasis and/or surgical margin who required adjuvant therapy. Conclusions:YAP/TAZ positivity is an independent predictive factor for survival in CCA patients after radical resectiony.
