Relationship between serum 25-hydroxy vitamin D level and ketosis-prone in newly-diagnosed type 2 diabetes mellitus
10.3760/cma.j.cn311282-20200515-00359
- VernacularTitle:新诊断2型糖尿病患者血清25-羟维生素D水平及其与酮症倾向的关系
- Author:
Shidi HU
1
;
Zhi CHEN
;
Qianzhen MO
;
Xingying CHEN
;
Tong ZHANG
;
Jie SHEN
Author Information
1. 南方医科大学第三附属医院内分泌代谢科，广东省骨科研究院，广东省骨与关节退行性疾病重点实验室，广州 510630
- Keywords:
Diabetes mellitus, type 2;
Ketosis-prone diabetes;
Vitamin D
- From:
Chinese Journal of Endocrinology and Metabolism
2021;37(8):709-714
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore relationship between serum 25-hydroxy vitamin D ( 25OHD ) level and ketosis-prone in patients with newly-diagnosed type 2 diabetes mellitus(T2DM).Methods:One hundred and thirty-four patients with newly diagnosed T2DM (103 males, 31 females) admitted in The Third Affiliated Hospital, Southern Medical University from January 2017 to January 2019 were enrolled into this study, including 36 patients with ketosis-prone (KPDM group) and 98 patients without ketosis(NKPDM group). Clinical characteristics, including height, weight, and history of hypertensive disease were collected. Serum 25OHD levels, lipid profile, islet function and glycosylated hemoglobin (HbA 1C)levels, ICA, IAA, GAD-Ab, etc., were measured. Results:Among the 134 patients, the patients with vitamin D deficiency, insufficiency, and sufficiency were 71 cases(52.99%), 52 cases(38.81%), and 11 cases(8.20%), respectively. KPDM group had significantly lower serum 25OHD level than NKPDM group[(44.12±9.77) nmol/L vs (55.35±15.31) nmol/L, P<0.01]. The rate of vitamin D deficiency was significantly higher in KPDM group compared to that in NKPDM group [(77.78% vs 43.88%), P<0.01]. The prevalence of KPDM varied significantly in different vitamin D status groups( P<0.01). Logistic regression analysis suggested that low serum 25OHD, younger age, high HbA 1C, and triglyceride were risk factors to ketosis-prone in newly diagnosed T2DM( P<0.01). Conclusion:Vitamin D deficiency is a common problem in newly diagnosed T2DM, especially in KPDM. Low serum 25OHD level seems to be an independent risk factor for ketosis-prone in patients with newly diagnosed T2DM.
