Association between pulse pressure and new-onset diabetes in overweight and obese people
10.3760/cma.j.cn311282-20201126-00785
- VernacularTitle:超重/肥胖人群的脉压与新发糖尿病的关联研究
- Author:
Wei FANG
1
;
Weijiang LI
;
Zefeng CAI
;
Mengyi ZHENG
;
Xu HAN
;
Guanzhi CHEN
;
Weiqiang WU
;
Zhichao CHEN
;
Shouling WU
;
Youren CHEN
Author Information
1. 汕头大学医学院 515000
- Keywords:
Pulse pressure;
New-onset diabetes mellitus;
Overweight and obese people
- From:
Chinese Journal of Endocrinology and Metabolism
2021;37(8):702-708
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between pulse pressure(PP) and new-onset diabetes in overweight and obese people.Methods:A prospective cohort study was conducted in overweight or obese participants selected from Kailuan Study who underwent 2006-2007 annual checkup and met the inclusion and exclusion criteria. PP was calculated by blood pressure and participants were divided into 4 groups according to PP quartile. The cumulative incidence of new-onset diabetes of different PP groups was calculated by Kaplan- Meier method and compare by Log- Rank test. The multivariate Cox proportional hazards model was used to analyze the association between different PP groups and new-onset diabetes. Results:During an average follow-up of 8.45 years, 8 922 diabetes was identified. The cumulative incidence rate of the Q1, Q2, Q3, and Q4 groups were 22.12%, 24.48%, 27.97%, and 33.44% respectively, which were statistically different( χ2=368.16, P<0.01). Cox proportional hazards regression analysis showed that after adjusting for multiple confounding factors, compared with Q1 group, the hazard ratio for diabetes in Q2, Q3, and Q4 groups were 1.07(1.00-1.14), 1.13(1.05-1.21), and 1.17(1.09-1.27) respectively. And the HR of diabetes event in pulse pressure(per 1 SD increase) was 1.04(1.02-1.07). Similar results were found in participants who were over-weight, obese, with normal blood pressure or hypertensive without drugs use. Conclusion:PP is positively correlated with the new-onset diabetes. High PP is one of the risk factors for developing diabetes in overweight and obese people.
