Effect of metformin use in pregnancy on pregnancy outcomes of women with polycystic ovary syndrome complicated with euglycemia and hyperinsulinemia
10.3760/cma.j.cn311282-20200720-00525
- VernacularTitle:孕期服用二甲双胍对血糖正常合并高胰岛素血症的多囊卵巢综合征妇女妊娠结局的影响
- Author:
Qing CHEN
1
;
Yaqian DUAN
;
Qicong LIU
;
Wei CHENG
;
Dongfang LIU
Author Information
1. 重庆医科大学附属第二医院内分泌与代谢病科 400010
- Keywords:
Polycystic ovary syndrome;
Metformin;
Hyperinsulinemia;
Pregnancy outcomes;
Pregnancy complications
- From:
Chinese Journal of Endocrinology and Metabolism
2021;37(6):529-533
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of metformin during pregnancy on pregnancy outcomes of women with polycystic ovary syndrome (PCOS) complicated with euglycemia and hyperinsulinemia.Methods:One hundred and thirty PCOS pregnant patients complicated with euglycemia and hyperinsulinemia admitted to the Second Affiliated Hospital of Chongqing Medical University from January 2017 to December 2019 were selected and divided into two groups, the treatment group was treated with metformin during pregnancy, and the control group was treated with lifestyle intervention. Pregnancy outcomes, pregnancy complications, delivery complications, first cesarean section rate, length, gestational age, weight, and blood glucose of the newborn were compared.Results:The incidence of early pregnancy loss (23.8% vs 6.0%, P=0.040), embryo damage(23.8% vs 4.5%, P=0.001), and premature rupture of membrane(21.3% vs 8.1%, P=0.047) in the treatment group were lower than those in the control group. There were no statistically significant differences in pregnancy complications, first cesarean section rate, length, weight, and blood glucose of the newborn and other adverse pregnancy outcomes ( P>0.05). Conclusion:Metformin therapy during pregnancy in PCOS patients can effectively reduce the incidence of early pregnancy loss, embryo damage , and premature rupture of membrane, improve pregnancy outcomes, and have no effect on the length, weight, and blood glucose of the newborn, with high safety and no obvious adverse events.
