Study of association between bile acid metabolites in early pregnancy and overweight
10.3760/cma.j.cn311282-20200720-00524
- VernacularTitle:妊娠早期胆汁酸代谢产物与超重之间的关联研究
- Author:
Ming GAO
1
;
Jinnan LIU
;
Junhong LENG
;
Weiqin LI
;
Xilin YANG
;
Jing LI
Author Information
1. 天津医科大学公共卫生学院 300070
- Keywords:
Early pregnancy;
Bile acids;
Overweight;
Lipid metabolism;
Gut microbiota
- From:
Chinese Journal of Endocrinology and Metabolism
2021;37(6):523-528
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study examined the associations between the levels of bile acids in early pregnancy and the occurrence of overweight.Methods:From 2010 to 2012, 22 302 pregnant women were recruited by Tianjin Women and Children′s Health Center to investigate gestational diabetes. Two hundred and forty-three women with gestational diabetes mellitus provided overnight fasting blood samples in the first trimester, and 243 counterparts without gestational diabetes mellitus matched on age were selected randomly to establish a nested case-control study. The association between bile acids and overweight were evaluated by binary logistic regression with data from 166 overweight pregnant women (body mass index≥24.0 kg/m 2) and 320 normal weight subjects (body mass index <24.0 kg/m 2). Results:Compared to non-overweight group, the level of primary unconjugated bile acids in overweight group was significantly higher. After adjustment of confounding factors, the OR of cholic acid (CA)>0.086 nmol/mL for overweight was 2.09 (95% CI 1.14-3.80, adjusted P=0.040), and OR of chenodeoxycholic acid (CDCA)>0.043 nmol/mL was 2.15 (95% CI 1.22-3.78, adjusted P=0.040) compared with the lower groups. However, the significant associations between the other bile acids and overweight were not detected. Stepwise selection was used to identify significant bile acid species in logistic regression. We found that only CA was independently associated with overweight, and the OR of CA>0.086 nmol/mL vs≤0.086 nmol/mL was 2.03 (95% CI 1.11-3.74, P=0.022). Conclusion:CA and CDCA in early pregnancy maybe associated with overweight, and CA might be independently associated with overweight.
