Effect of diabetes mellitus on pulmonary uptake of sevoflurane
10.3760/cma.j.cn131073.20200918.01017
- VernacularTitle:糖尿病因素对患者七氟烷肺摄取的影响
- Author:
Li AN
1
;
Yanqiu LIU
;
Hong GAO
;
Hongwei DUAN
;
Yi ZHONG
;
Yang LIU
;
Huaibiao ZHAO
;
Youqin HE
;
Guilong WANG
Author Information
1. 贵州医科大学附属医院麻醉科，贵阳 550004
- Keywords:
Diabetes mellitus;
Anesthetics, inhalation;
Respiratory tract absorption
- From:
Chinese Journal of Anesthesiology
2021;41(10):1227-1229
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of diabetes mellitus on pulmonary uptake of sevoflurane.Methods:Twenty patients with type 2 diabetes mellitus, aged 40-64 yr, with body mass index of 18.5-22.9 kg/m 2, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, undergoing elective surgery with general anesthesia, served as diabetes group (group D). Twenty non-diabetic patients matched by age, gender and surgery were selected as control group (group C). After anesthesia induction and tracheal intubation, sevoflurane was inhaled at a concentration of 2% (oxygen flow 2 L/min). The inhaled concentration (Fi) and exhaled concentration (Fa) at 1, 3, 5, 10, 15, 20 and 30 min of inhalation of sevoflurane were recorded, and the Fa/Fi ratio was calculated.The time required for the Fa/Fi ratio to reach 0.7 was recorded. Results:Compared with group C, the Fa/Fi ratio was significantly increased at each time point, and the time required for the Fa/Fi ratio to reach 0.7 was shortened in group D ( P<0.05). Conclusion:Diabetes mellitus can reduce pulmonary uptake of sevoflurane in the patients.
