Obesity-Related Digestive Diseases and Their Pathophysiology.
- Author:
Su Youn NAM
1
Author Information
- Publication Type:Review
- Keywords: Obesity; Gastrointestinal disease; Cytokines
- MeSH: Adipokines; Carcinoma, Hepatocellular; Cholangiocarcinoma; Colon; Cytokines; Esophageal Diseases; Esophageal Neoplasms; Esophagus; Gallstones; Gastroesophageal Reflux; Gastrointestinal Diseases; Hepatitis; Insulin Resistance; Non-alcoholic Fatty Liver Disease; Obesity; Pancreatic Neoplasms; Polyps; Public Health; Weight Loss
- From:Gut and Liver 2017;11(3):323-334
- CountryRepublic of Korea
- Language:English
- Abstract: Obesity is a growing medical and public health problem worldwide. Many digestive diseases are related to obesity. In this article, the current state of our knowledge of obesity-related digestive diseases, their pathogenesis, and the medical and metabolic consequences of weight reduction are discussed. Obesity-related digestive diseases include gastroesophageal reflux disease, Barrett’s esophagus, esophageal cancer, colon polyp and cancer, nonalcoholic fatty liver disease, hepatitis C-related disease, hepatocellular carcinoma, gallstone, cholangiocarcinoma, and pancreatic cancer. Although obesity-related esophageal diseases are associated with altered mechanical and humoral factors, other obesity-related digestive diseases seem to be associated with obesity-induced altered circulating levels of adipocytokines and insulin resistance. The relationship between functional gastrointestinal disease and obesity has been debated. This review provides a comprehensive evaluation of the obesity-related digestive diseases, including pathophysiology, obesity-related risk, and medical and metabolic effects of weight reduction in obese subjects.
